It has been found that when ipriflavone is used with sufficient calcium it tends to prevent bone loss. However, if the mineral density of the bone is lost, it will not restore it.Its usage should also be medically supervised as it can have interactions with different medications and can possibly lower the level of white blood cells.As against the general belief that ipriflavone substance is natural, it is actually a synthetic compound that has been derived in a lab from the isoflavone (daidzein) gotten from soy.

In Turkey, Italy and Japan, it can be obtained as a prescription drug.It can also be obtained in health food stores just as its own or as an ingredient found in calcium supplements, for example, Ostivone obtainable at Medicine Direct. However, it is not an essential nutrient that can be found in food.


The Way Ipriflavone Works
Ipriflavone and estrogen have a similar chemical structure that allows it to constrain osteoclast activities that are bone-degrading.
It does it without the stimulation of uterine and breast tissue or increasing cancer risk.


What the Results from Research Say
There are a lot of studies undertaken that are placebo-controlled and double-blinded that has involved more than 1,700 partakers.These studies examined the effects of the supplements on different kinds of osteoporosis.It has suggested that when used together with sufficient calcium, it can reduce the development of osteoporosis and probably reverse it to some degree while reducing fracture pains.

To cite an example, a double-blind study was undertaken for two years.It involved almost 200 postmenopausal women that indicated a bone density loss of 0.7% in a placebo group while recording a 1% gain for the supplement group.However, another study which was larger and longer did not find any benefit from the use of the supplement.In the study, 474 postmenopausal women were tried for three years and the results experienced were alike in the placebo and supplement group.

The study had only given 500 mg of daily calcium to participants, unlike various other studies that had given 1,000 mg of daily calcium to participants in the supplement program.It is interesting to note that this study had not administered vitamin D supplements that are necessary for the absorption of calcium to the participants.


The Aftereffect
One of the generally known aftereffects of using the supplement is that there are complaints on digestive issues and sometimes the sensitive ones have diarrhoea.The product Osteofix 200, manufactured by the Italian manufacturer, Chiesi Pharmacy, has warned patients sensitive to the drug of some aftereffect.Some of these are gastrointestinal issues like diarrhoea, nausea, gastralgia, vomiting and dizziness, and also itchiness and skin rashes.


Notwithstanding, the majority of the 3,000 participants that utilized the supplement in clinical studies have not experienced any serious aftereffects.The largest study involving the trial of nearly 500 women in Europe during a 3-year double-blind study showed that the levels of white blood cells can be reduced.These are lymphocytes and as they are reduced, the immune system is compromised.
These are in line with the warnings issued by Chiesi Pharmacy on the occasional observations made on the reductions in white and red cells.It has been recommended by researchers that the supplement should not be taken by the following:


  • Pregnant and lactating women
  • People with immune deficiencies like HIV
  • Conditions that require drugs like cyclosporine, methotrexate, or corticosteroids that tend to subdue the immune system.
  • People with severe kidney disease
  • Ulcer patients


It has also been evidenced that using the supplement together with estrogen might increase the possibility of breast and uterine cancer.



Interactions with Other Drugs
When Ipriflavone interferes with some drugs, they affect the way it is processed in the liver.
Research has shown that it interferes with the following drugs:


  • Theophylline, a drug for asthma patients
  • Tolbutamide, medication for the diabetic
  • Dilantin/Phenytoin administered to the epileptic
  • Coumadin/Warfarin for blood thinning


The supplement might change the levels of these medications in a patient's body and can also increase caffeine levels when someone takes coffee or some other cola drinks.


The most common recommended dose is 200mg thrice daily after meals or 300mg two times a day.
It has to be taken together with calcium of a minimum of 1,000mg every day and vitamin D supplement.
This helps to sustain the blood levels within the suggested range all through the winter period.
Treatment over a long period of time is yet to show any accumulated supplement that might be harmful and cases of overdose are yet to be known.


Ipriflavone can be an option for those who are looking for a natural solution to their bone loss.
However, it should only be used with a traditional supplement program that combines sufficient calcium, magnesium, vitamin K2 and vitamin D3.
As this program becomes stable, the intake vitamin D needs to be adjusted to make sure that blood levels remain in the recommended range all through the winter.

Our Team

Excellent Team Members

Peter Parker

Departmental Head

Michael Loe


Mary Jane

Departmental Head

Steven Carl


Interactions with Other Drugs










what our customers say
  • When it is included in daily routine strontium citrate can be considered for addition in a program for natural bone health.

    John Frank
  • If rapid bone loss continues despite the above program, the adding of ipriflavone might be considered with medical supervision.

    Michael Doe
  • Lymphocyte and white blood cell count should be undertaken before the use of the supplement, after six months and then every year.

    Thomas Carl

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